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KMID : 0545120200300040599
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 4 p.599 ~ p.603
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IL-10 Expression-Inducing Gut Bacteria Alleviate High-Fat Diet-Induced Obesity and Hyperlipidemia in Mice
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Kim Hye-In
Yun Soo-Won
Han Myung-Joo
Jang Se-Eun
Kim Dong-Hyun
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Abstract
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In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.
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KEYWORD
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Gut bacteria, IL-10, obesity, liver steatosis, colitis
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